Binding of 3H-labeled benzo(a)pyrene to DNA in hamster tracheal epithelial cells.
نویسندگان
چکیده
Isolated tracheas were incubated in vitro in the presence of tritiated benzo[a]pyrene. Highly purified DNA was isolated from the epithelial cells of these tracheas and was found to contain bound BP-3H. If tracheas were obtained from hamsters previously treated intratracheally with benzo[a]pyrene plus Fe2O3, this binding was enhanced. Incuba tion of tracheas in the presence of 7,8-benzoflavone or at a temperature of 0°resulted in inhibition of this enhanced
منابع مشابه
Benzo(a)pyrene and 7,12-Dimethylbenz(a)anthracene Metabolism and DMA Adduct Formation in Primary Cultures of Hamster Epidermal Cells1
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عنوان ژورنال:
- Cancer research
دوره 33 11 شماره
صفحات -
تاریخ انتشار 1973